Supplement Facts

**Daily Value not established.

Benefits of AGYL for Joint Health: What is it? - Does it work?

Nearly 1 in 4 adults in the U.S., suffer from conditions like arthritis, gout, or fibromyalgia. In addition to physical suffering, joint-related conditions often cause work disability, with increased costs for medical care and lost earnings. Joints play a critical role in the musculoskeletal system and bone health, so it is essential to care for them to live a full, active life free of mobility limitations. The best way to care for your joints is to keep your muscles, ligaments, and bones resilient and stable.

Obesity is one of the biggest risk factors for osteoarthritis since the joints have to work much harder to support excess weight. Research has shown that the knees are subjected to four times more stress with each extra pound of body weight. So maintaining a healthy weight for your body type along with exercising, a healthy diet and taking the right supplements are the most important things you can do for your joints.

AGYL for Joint Support has been formulated with all of the key ingredients that are scientifically proven to reduce pain and inflammation, protect cartilage, aid absorption and enrich the joints and bones with the vitamins and minerals they need to remain strong and healthy. The formula includes Vitamin C, cucumber extract, turmeric extract and chicken cartilage, which are proven to modulate our body’s pro-inflammatory immune response through the manipulation of various cytokines.

Vitamin C

Vitamin C, also known as L-ascorbic acid, is an essential nutrient that is not freely synthesized in humans and is an antioxidant that helps protect against free radicals that damage cells. For joint health and arthritis treatment, Vitamin C serves as a cofactor in collagen synthesis. Collagen is the primary protein that makes up cartilage, which lines and protects our joints. Vitamin C also modulates the pro-inflammatory cytokine response, helping to reduce inflammation.

Studies have shown that one of the major contributors to the development of degenerative osteoarthritis is the accumulation/deposition of free radicals (superoxide, hydrogen peroxide, peroxynitrite) in joints. These free radicals induce genetic instability within chondrocytes, reducing the amount of viable cartilage. Vitamin C is one of the main antioxidants within the body that can eliminate excess free radicals, providing protection to joints.(1)

The strongest evidence for the use of Vitamin C in the prevention of osteoarthritis came from a 2011 prospective cohort study. (2)

● 1,023 participants underwent biennial, sequential knee radiographs, which were assessed using the Kellgren-Lawrence scale, to evaluate the incidence of OA and the progression of RKOA.

● Individuals without baseline knee OA who self-reported vitamin C supplement usage were 11 % less likely to develop knee OA than were those individuals who self-reported no vitamin C supplement usage (risk ratio (RR) = 0·89, 95 % CI 0·85, 0·93).

● Among those participants with RKOA at baseline, vitamin C supplement usage did not demonstrate an association with RKOA progression (RR = 0·94, 95 % CI 0·79, 1·22).

● Thus, Vitamin C may provide a preventative role in the development of OA; however, it has not shown to help slow the progression of OA.

Cucumber Extract

Cucumber extract - Cuvitus, is rich in Vitamins A, C, and K, and contains phytochemicals that are considered anti-inflammatory. Literature shows that cucumber extract contains iminosugars. Iminosugars act as inhibitors or enhancers of carbohydrate-processing enzymes, suggesting their potential use as therapeutics for modulation of the immune response. To date, iminosugars have also been used to treat various ailments such as HIV, HSV, CSF, and diabetes. (3)

In 2018, a double blinded, randomized control trial was conducted and compared the effectiveness of Cucumis sativus extract (CSE) and glucosamine chondroitin (GC) on osteoarthritis pain management. (4)

● 122 patients (56 males and 66 females) between 40 and 75 years of age and diagnosed with moderate knee OA were included in this trial.

● The Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog scale, and Lequesne’s Functional Index were used to evaluate pain, stiffness, and physical function of knee OA in participants at baseline (Day 0) and on Days 30, 60, 90, 120, 150, and 180.

● In the GC group, the average WOMAC score was reduced by 14.80% on Day 30 and 33.7% on Day 180 compared with the baseline value (Day 0). From baseline, CSE reduced the WOMAC score by 29.80% at Day 30 and 70.3% at Day 180. From baseline, GC reduced the VAS by 12.34% at Day 30 and by 25.6% at Day 180.

● In the CSE group, there was a 24.02% and 46.3% reduction from baseline at Day 30 and Day 180, respectively. Both GC and CSE reduced LFI scores. In the GC group, there was a 3.06% and 7.5% score reduction at Day 30 and Day 180, respectively.

● In the same time periods, there was a 15.36% and 26.9% reduction in the CSE group.

● The proprietary cucumber extract (CSE) administered at a dose of 10 mg twice daily brought significant pain relief to participants. The low dose of this natural extract makes it a lot more attractive than conventional OA management regimes.

Turmeric Extract

Curcumin is the “active ingredient” found in turmeric. Curcumin is a curcuminoid and a member of the ginger family. The proposed mechanism of action is not entirely known; however, it is hypothesized that curcumin helps regulate pro-inflammatory cytokine responses.

A study of 50 patients with osteoarthritis evaluated the efficacy of 200 mg of curcumin per day. (5)

● The signs and symptoms of osteoarthritis were evaluated with use of WOMAC scores, an indicator of pain level. The mobility was assessed by walking performance (treadmill), and inflammatory status was assessed by measuring the levels of CRP.

● After 3 months of treatment, the global WOMAC score was decreased by 58%; walking distance was increased from 76 m to 332 m, and CRP levels were significantly decreased.

● In comparison, only modest improvement in these measurements was observed in the control group.

Chicken Cartilage

Chicken Cartilage contains UC-II which is a form of undenatured type II collagen derived from chicken sternum. Type II collagen is the primary protein that makes up the cartilage that lines our joints. In vivo model of collagen induced arthritis (CIA), demonstrated that ingesting microgram quantities of undenatured type II collagen significantly reduces circulating levels of inflammatory cytokines, potentially serving to decrease both the incidence and the severity of arthritis. (6)

Research into its mechanism of action has revealed that several distinct types of T regulator cells mediate this phenomenon by releasing IL-10 and TGF-β. A 2013 randomized control trial showed promising results, which supported the use of UC-II Chicken Cartilage in the treatment of OA. (7)

● After 120 days of supplementation, subjects in the UC-II group exhibited a statistically significant improvement in average knee extension compared to placebo (81.0 ± 1.3º vs 74.0 ± 2.2º; p = 0.011) and to baseline (81.0 ± 1.3º vs 73.2 ± 1.9º; p = 0.002).

● The UC-II cohort also demonstrated a statistically significant change in average knee extension at day 90 (78.8 ± 1.9º vs 73.2 ± 1.9º; p = 0.045) versus baseline.

● It was also noted that the UC-II group exercised longer before experiencing any initial joint discomfort at day 120 (2.8 ± 0.5 min, p = 0.019), compared to baseline (1.4 ± 0.2 min).

● By contrast, no significant changes were seen in the placebo group.

● Daily supplementation with 40 mg of UC-II was well tolerated and led to improved knee joint extension in healthy subjects.

● UC-II also demonstrated the potential to lengthen the period of pain free strenuous exertion and alleviate the joint pain that occasionally arises from such activities.

Hops Extract

The AGYL specialized formula also includes hops extract, a natural ingredient that increases the level of the neurotransmitter GABA. High levels of GABA correlate with decreased levels of chronic arthritic pain. The hop (Humulus lupulus), a component of beer, is a sedative plant whose pharmacological activity is due principally to its bitter resins.

The mechanism of action of the resin of hop consists of increasing the activity of the neurotransmitter γ-aminobutyric (GABA), inhibiting the central nervous system (CNS). The exact effects of GABA on the management of osteoarthritis are not greatly described in the literature.

One study found that levels of GABA are inversely proportional to the intensity of knee pain associated with osteoarthritis. Increasing the levels of GABA via hops extract could reduce the pain associated with chronic osteoarthritis. (5)

Black Pepper Extract

To enhance absorption and ensure your body is optimizing our precise formula, we have added Bioperine, a black pepper extract which has been clinically proven to enhance the bioavailability of nutrients. Black pepper extract (BioPerine®) is a standardized extract, prepared from the dried fruits of Piper nigrum (black pepper) and contains a minimum of 95% Piperine. Bioperine has been found to significantly increase the bioavailability of curcumin, the primary curcuminoid found in turmeric.

Important mechanisms of increasing bioavailability via Bioprene include inhibition of P-glycoprotein, inhibition of enzymes involved in glucuronidation, and thermogenesis. A clinical study done at St. John’s Medical College, Bangalore, India and published in Planta Medica journal in 1997 provided clinical evidence of piperine’s role in increasing the bioavailability of Curcumin. (8)

● BioPerine® significantly improved the uptake of Curcumin—the healthful extract from turmeric roots with clinically validated efficacy in a wide range of health conditions ranging from inflammation to cancer.

● Bioavailability of Curcumin (2000 mg) when co-administered with BioPerine® (20 mg) was enhanced by 20-fold or 2000% compared to bioavailability of Curcumin alone at doses that were devoid of adverse side effects.

OTHER INGREDIENTS: Gelatin, Microcrystalline Cellulose, Magnesium Stearate Vegetable Grade, Silicon Dioxide.

Conclusion:

The importance of maintaining healthy joints cannot be overemphasized, so it is essential to care for them in order to live a full, active life absent of mobility limitations. If you are interested in learning more about the AGYL Joint Health Supplement please visit liveagyl.com.